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RNA m<sup>6sup>A modification and its function in diseases
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 481-489 doi: 10.1007/s11684-018-0654-8
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.
《医学前沿(英文)》 页码 907-923 doi: 10.1007/s11684-023-1009-7
动态二叉树表示环境的A<sup>*sup>算法及其在足球机器人路径规划中的实现
唐平,杨宜民
《中国工程科学》 2002年 第4卷 第9期 页码 50-53
提出采用二叉树表示二维空间的方法,对全局路径规划和局部路径规划进行综合考虑,设计移动机器人在复杂环境下对动态障碍物进行避障的A<sup>*sup>算法。
关键词: 动态二叉树 A<sup>*sup>算法 路径规划
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 608-620 doi: 10.1007/s11684-021-0836-7
关键词: t(8 21)(q22 q22) AML CD34+CD117dim/ CD34+CD117bri cell population gene expression prognosis
K<sup>+sup> and Na<sup>+sup> fluxes in roots of two Chinese Iris populations
Pinfang LI,Biao ZHANG
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 144-149 doi: 10.15302/J-FASE-2014016
关键词: Iris lactea Pall. var. chinensis (Fisch.) Koidz population K+ and Na+ ion flux non-invasive micro-test technique
全氟化碳乳剂<sup>19sup>F磁共振成像的最新进展 Review
Wickline,Gregory M. Lanza
《工程(英文)》 2015年 第1卷 第4期 页码 475-489 doi: 10.15302/J-ENG-2015103
<sup>19sup>F磁共振成像(MRI) 的研究可追溯到30多年前。在这30多年间,氢原子核(<sup>1sup>H)成像技术迅速发展,并在全球得到广泛应用,使得磁共振成像成为生物医学诊断成像技术中不可缺少的支柱。多年来,由于各种原因,对<sup>19sup>F成像技术的研究进展缓慢。但是在过去的十年间,尤其是最近几年,<sup>19sup>F成像的研究和临床相关性呈爆发式发展。部分原因归结为MRI仪器、<sup>19sup>F/<sup>1sup>H线圈设计以及临床前和临床核磁共振仪的超高速脉冲序列的发展。这些成就再加上对解剖生理学分子成像技术的兴趣以及一批创新造影剂的出现使<sup>19sup>F的概念进入了早期的临床评估中。
Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification
《环境科学与工程前沿(英文)》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1674-4
● Simultaneous NH4+/NO3– removal was achieved in the FeS denitrification system
Haiping LUO,Bangyu QIN,Guangli LIU,Renduo ZHANG,Yabo TANG,Yanping HOU
《环境科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 522-527 doi: 10.1007/s11783-014-0633-5
Advances of 12<sup>thsup> CAPS research symposium: young chemists and chemical engineers fronts
Guoping Hu, Baiqian Dai
《化学科学与工程前沿(英文)》 2021年 第15卷 第3期 页码 461-463 doi: 10.1007/s11705-020-2026-6
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1986-2000 doi: 10.1007/s11705-023-2337-5
关键词: sp3/sp2-hybridized C–N bond noble metal nanoparticle catalytic active site turnover frequency DFT
Symbiotic performance, shoot biomass and water-use efficiency of three groundnut (
Sofiya K. MUHABA, Felix D. DAKORA
《农业科学与工程前沿(英文)》 2020年 第7卷 第4期 页码 455-466 doi: 10.15302/J-FASE-2020354
Phosphorus is a key nutrient element involved in energy transfer for cellular metabolism, respiration and photosynthesis and its supply at low levels can affect legume nodulation, N fixation, and C assimilation. A two-year field study was conducted in Ethiopia in 2012 and 2013 to evaluate the effects of P supply on growth, symbiotic N nutrition, grain yield and water-use efficiency of three groundnut genotypes. Supplying P to the genotypes significantly increased their shoot biomass, symbiotic performance, grain yield, and C accumulation. There was, however, no effect on shoot δ C values in either year. Compared to the zero-P control, supplying 40 kg·ha P markedly increased shoot biomass by 77% and 66% in 2012 and 2013, respectively. In both years, groundnut grain yields were much higher at 20 and 30 kg·ha P. Phosphorus supply markedly reduced shoot δ N values and increased the %Ndfa and amount of N-fixed, indicating the direct involvement of P in promoting N fixation in nodulated groundnut. The three genotypes differed significantly in δ N, %Ndfa, N-fixed, grain yield, C concentration, and δ C. The phosphorus × genotype interaction was also significant for shoot DM, N content, N-fixed and soil N uptake.
关键词: shoot yield N-fixed %Ndfa δ15N δ13C water-use efficiency
Effects of La, Ce on nitrogen removal in sequencing batch reactor
Qing XIA , Rui LIANG , Yuning HONG , Lili DING , Hongqiang REN , Yuxiang MAO , Mingyu ZHAO ,
《环境科学与工程前沿(英文)》 2009年 第3卷 第3期 页码 369-374 doi: 10.1007/s11783-009-0036-1
关键词: rare earth La3+ Ce3+ inorganic nitrogen nitrogen removal sequencing batch reactor
Innate and adaptive T cells in influenza disease
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《医学前沿(英文)》 2018年 第12卷 第1期 页码 34-47 doi: 10.1007/s11684-017-0606-8
Influenza is a major global health problem, causing infections of the respiratory tract, often leading to acute pneumonia, life-threatening complications and even deaths. Over the last seven decades, vaccination strategies have been utilized to protect people from complications of influenza, especially groups at high risk of severe disease. While current vaccination regimens elicit strain-specific antibody responses, they fail to generate cross-protection against seasonal, pandemic and avian viruses. Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized. During natural infection, viral replication is initially controlled by innate immunity before adaptive immune responses (T cells and antibody-producing B cells) achieve viral clearance and host recovery. Adaptive T and B cells maintain immunological memory and provide protection against subsequent infections with related influenza viruses. Recent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells) in controlling influenza and linking innate and adaptive immune mechanisms, thus making them attractive targets for vaccination strategies. We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptive CD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel vaccine strategies to elicit cross-protective immunity against different influenza strains and subtypes.
关键词: influenza innate T cells CD4+ and CD8+ T cells vaccination
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
《医学前沿(英文)》 2023年 第17卷 第2期 页码 263-274 doi: 10.1007/s11684-022-0935-0
关键词: melanoma neuropilin and tolloid-like 2 Ca2+/CaMKII signaling pathway
新型400 km·h<sup>−1sup> 级架空接触网监测技术
Chul Jin Cho, Young Park
《工程(英文)》 2016年 第2卷 第3期 页码 360-365 doi: 10.1016/J.ENG.2016.03.016
近年来,高速铁路各项技术不断发展,列车运行速度从300 km•h–1 提高到400 km•h<sup>−1sup>。本文介绍了由韩国研究者开发和论证的技术,即400 km•h<sup>−1sup> 级集电性能评估方法。
关键词: 高速铁路 架空接触网 状态监测 基于图像处理的测量方式
标题 作者 时间 类型 操作
High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast
期刊论文
Clinical significance of CD34<sup>+sup>CD117<sup>dimsup>/CD34<sup>+sup>CD117<sup>brisup> myeloblast-associated
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
期刊论文
K<sup>+sup> and Na<sup>+sup> fluxes in roots of two Chinese Iris populations
Pinfang LI,Biao ZHANG
期刊论文
Advances of 12<sup>thsup> CAPS research symposium: young chemists and chemical engineers fronts
Guoping Hu, Baiqian Dai
期刊论文
Effect of noble metal nanoparticle size on C–N bond cleavage performance in hydrodenitrogenation: a study of active sites
期刊论文
Symbiotic performance, shoot biomass and water-use efficiency of three groundnut (
Sofiya K. MUHABA, Felix D. DAKORA
期刊论文
Effects of La, Ce on nitrogen removal in sequencing batch reactor
Qing XIA , Rui LIANG , Yuning HONG , Lili DING , Hongqiang REN , Yuxiang MAO , Mingyu ZHAO ,
期刊论文